These are our laboratory have shown that

Outer membrane protein (OmpA) is a class of proteins are well preserved in the family Enterobacteriaceae and in evolution. Klebsiella pneumonia is the gram-negative pathogens kapsulyrovannoy. This is an important cause of community acquired pneumonia and nosocomial. Evidence

indicates that

K. pneumonia infection characterized by a lack of early inflammatory response. These are our laboratory showed that K. pneumonia

CPS helps suppress the host inflammatory response. However, do not know whether the

K. pneumonia using additional factors that modulate many inflammatory reactions. Here we report that K strattera dosage. pneumonia

OmpA is important for immune evasion in vitro and in vivo. Infection of A549 cells and normal human bronchial 52OmpA2,

ompA mutant, increased IL-8. 52145-D

WCA ompA, which do not express CPS and

ompA,

prompted a high level of IL-8. And mutants can be complemented. In vivo, 52OmpA2 induced higher levels of TNF

,

Ls, and

IL6, than wild type. ompA mutants activated NF-JB and phosphorylation of p38, p44/42 and JNK MAPKs and IL-8 was induced by NF-JB-dependent and p38

and p44/42-dependent way. 52OmpA2 engaged TLR2 and -4 to activate NF-JB, and 52145-D

WCA ompA activate not only TLR2 and TLR4, but NOD1. Finally, we show that

ompA mutant reduced in mouse models of pneumonia. The results of this study show that C. pneumonia

OmpA contributes to weakening the answers airway cells. This may contribute to pathogen survival in a hostile environment

light. .